Category:
Chiral Intermediates
CAS NO:
1421372-94-2
Standard:
In-house Standards,
AZD9291 intermediate
This compound, identified as N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyrimidin-2-amine, is a specialized heterocyclic intermediate utilized in pharmaceutical synthesis. Its core process involves nucleophilic aromatic substitution coupled with indole coupling reactions. The molecular formula is C20H16FN5O3, and it corresponds to CAS No. 1879204-58-7.
Strict adherence to GMP standards is required during handling. Store under inert atmosphere at temperatures below -20°C to prevent degradation. Personnel must utilize appropriate PPE due to potential mutagenic properties associated with nitro-substituted aromatic structures.