Appearance:
Off-White Powder
Molecular Weight:
376.2533
Boiling Point:
430 °C at 760 mmHg
Melting Point:
168-170°C
Flash Point:
213.9 °C
Usage:
A new experimental anticonvulsant drug. Anxiolytic.
*The following content is generated by AI and is for reference only.
Overview
Retigabine Dihydrochloride (CAS 146290-77-5) is the dihydrochloride salt of ezogabine, a potassium channel opener. Molecular formula: C15H18Cl2N2O. Synthesized via chlorination of retigabine base to enhance water solubility and stability for pharmaceutical formulation.
Application
- Neurology: Adjunctive therapy for refractory partial-onset seizures in adults.
- R&D: Pharmacological tool for studying KCNQ potassium channel modulation.
- API Manufacturing: Active Pharmaceutical Ingredient for antiepileptic drug development.
Precautions
Restricted use due to skin pigmentation risks; requires strict patient monitoring. Store in cool, dry conditions away from light. Handle with PPE to avoid inhalation or dermal contact during processing.