Rosuvastatin is a selective inhibitor of HMG-CoA reductase. HMG-CoA reductase inhibitor is the rate-limiting enzyme of the transition hydroxy-3-methylglutaryl coenzyme A to valerate A (The precursor of cholesterol).
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Overview
Rosuvastatin calcium is a synthetic HMG-CoA reductase inhibitor used primarily for lipid management. Manufactured via advanced organic synthesis, its molecular formula is C22H28CaF2N2O10S and CAS No. 147091-46-9.
Application
- Pharmaceutical Manufacturing: Active pharmaceutical ingredient (API) for treating hyperlipidemia.
- Cardiovascular Therapy: Reduces LDL cholesterol and triglycerides in high-risk patients.
- Generic Formulation: Bulk supply for immediate-release tablets and capsules.
Precautions
Contraindicated in pregnancy and severe hepatic impairment. Store in sealed containers at controlled room temperature to prevent moisture degradation. Handle with PPE to avoid inhalation or skin contact.