Category:
Prophylactic Biological Products
CAS NO:
1190307-88-0
Standard:
In-house Standards,
Sofosbuvir is a pyrimidine nucleotide analogue (Fig. 1) that inhibits HCV NS5B RNA-dependent RNA polymerase, which is essential for viral replication, Sofosbuvir is a prodrug that undergoes intracellular metabolism in human hepatocytes to a pharmacologically active uridine triphosphate form (GS-461203).
Sofosbuvir is a nucleotide analog prodrug for treating Hepatitis C. Synthesized via phosphoramidite chemistry, its molecular formula is C22H29FN6O8P with CAS 850157-04-3.
Contraindicated with amiodarone due to bradycardia risks. Store at 25°C in moisture-proof containers. Handle with PPE to avoid inhalation of fine powders.