Sunitinib Malate (SU 11248 Malate) is a potent tyrosine kinase inhibitor targeting VEGFR2 and PDGFRβ with IC50s of 80 nM and 2 nM, respectively
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Overview
Sunitinib malate is a multi-targeted tyrosine kinase inhibitor used in oncology. It acts by blocking receptors for VEGF and PDGF. Molecular Formula: C22H27F2N5O6. CAS No.: 557795-19-4.
Application
- Renal Cell Carcinoma (RCC): First-line treatment for advanced kidney cancer.
- Gastrointestinal Stromal Tumors (GIST): Management of imatinib-resistant cases.
- Pancreatic Neuroendocrine Tumors (pNET): Delaying tumor progression.
Precautions
Strictly monitor blood pressure, liver function, and cardiac status. Store at controlled room temperature (20°C–25°C) in a dry, light-protected environment to maintain stability.