A fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection.
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Overview
Tenofovir Alafenamide Fumarate is a prodrug of tenofovir used in HIV and HBV therapy. Synthesized via phosphoramidate coupling, its molecular formula is C14H23N6O7P·C4H4O4 with CAS No. 1350782-76-9.
Application
- Pharmaceutical Manufacturing: Key API for fixed-dose combination antiretroviral tablets.
- Virology Research: Used in clinical trials for novel nucleotide analog efficacy studies.
- Contract Production: Sourced by generic drug manufacturers for global supply chains.
Precautions
Store below 25°C in dry conditions to prevent hydrolysis. Strict adherence to GMP is required during handling to ensure purity and avoid cross-contamination with other active pharmaceutical ingredients.