Tofacitinib citrate is a JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively
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Overview
Tofacitinib Citrate (CAS: 1247525-61-8) is the citrate salt of a Janus kinase (JAK) inhibitor. It features the molecular formula C19H28N6O7. This intermediate is synthesized via specific pharmaceutical processes to enhance solubility and stability for drug formulation.
Application
- Rheumatology: Treatment of moderate-to-severe rheumatoid arthritis.
- Dermatology: Management of active ulcerative colitis and psoriasis.
- Pharmaceutical Manufacturing: API production for oral tablet formulations.
Precautions
Strictly monitor for serious infections, malignancies, and thrombosis. Store in a cool, dry place below 25°C away from direct sunlight. Handle with appropriate PPE to avoid inhalation or skin contact.