Appearance:
white to off-white crystalline powder
Molecular Weight:
400.63706
Density:
1.01 g/cm3
Boiling Point:
531.5oC at 760 mmHg
Melting Point:
136oC
Flash Point:
222.6 oC
Storage Temperature:
?20°C
Refractive index:
1.534
Solubility:
Insoluble
Stability:
Stable at normal temperatures and pressures.
*The following content is generated by AI and is for reference only.
Overview
Alfacalcidol is a synthetic vitamin D analogue used primarily in pharmaceutical manufacturing. The core process involves hydroxylation of 1-alpha-hydroxyvitamin D2 or D3. Its molecular formula is C27H44O2 and CAS number is 4158-96-5.
Application
- Treatment of renal osteodystrophy and hypocalcemia in chronic kidney disease patients.
- Management of secondary hyperparathyroidism following parathyroidectomy.
- Formulation of oral solutions, capsules, and injectables for metabolic bone disorders.
Precautions
Contraindicated in cases of hypercalcemia or hypersensitivity to vitamin D. Storage requires protection from light at controlled room temperature (15-25°C). Strict adherence to dosage guidelines is mandatory to prevent toxicity.