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Overview
Enarodustat is a potent hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) developed for treating anemia in chronic kidney disease. Its molecular formula is C20H18N4O3S and CAS number is 1679695-44-3. The core synthesis involves complex heterocyclic coupling reactions.
Application
- Pharmaceutical manufacturing: Active Pharmaceutical Ingredient (API) production for oral anemia therapies.
- Clinical trials: Investigational use in managing anemia associated with CKD stages 3-5.
- Research & Development: Target validation studies for HIF pathway modulation in hematology.
Precautions
Strict adherence to GMP standards is required during handling. Storage must be maintained below 25°C in a dry, well-ventilated area away from direct sunlight. Clinical administration requires monitoring of blood pressure and thrombotic risks due to HIF stabilization effects.