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Overview
Naldemedine tosylate is a synthetic opioid receptor antagonist used for treating chronic idiopathic constipation. Its core synthesis involves precise chiral resolution and salt formation. The compound features the molecular formula C25H31NO7S·C7H8O3S and CAS number 1496807-74-1.
Application
- Pharmaceutical manufacturing of oral tablets for IBS-C patients.
- Oncology supportive care to manage opioid-induced constipation.
- R&D supply for clinical trials evaluating gut motility agents.
Precautions
Contraindicated in cases of gastrointestinal obstruction or severe hepatic impairment. Storage requires sealed containers at 25°C with strict humidity control below 40% to prevent hydrolysis.