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Overview
Resmetirom is a first-in-class, small-molecule thyroid hormone receptor-beta agonist developed for treating metabolic dysfunction-associated steatohepatitis (MASH). Its core synthesis involves complex organic coupling and stereochemical control. The compound features the molecular formula C26H28ClF2N3O5S with CAS No. 1974065-53-8.
Application
- Pharmaceutical Manufacturing: Used as an active pharmaceutical ingredient (API) for developing oral tablets targeting non-alcoholic fatty liver disease.
- Clinical Research: Serves as a critical reagent in Phase III trials to evaluate efficacy on liver fibrosis and inflammation markers.
Precautions
Strictly adhere to clinical dosage protocols due to potential drug-drug interactions. Store API in sealed containers at controlled room temperature (20-25°C) protected from light and moisture to maintain chemical stability.