Appearance:
Pale yellow to yellow crystalline powder
Molecular Weight:
677.19
Density:
==
Boiling Point:
873.4 °C at 760 mmHg
Melting Point:
250-256℃ (dec.)
Flash Point:
482 °C
*The following content is generated by AI and is for reference only.
Overview
Irinotecan hydrochloride trihydrate is a water-soluble prodrug of camptothecin used in oncology. Synthesized via chemical modification, its molecular formula is C33H38N4O4·HCl·3H2O with CAS No. 121403-73-6.
Application
- Chemotherapy for metastatic colorectal cancer.
- Combination therapy with 5-fluorouracil and leucovorin.
- Treatment of small cell lung cancer in specific regimens.
Precautions
Requires strict monitoring for delayed diarrhea and neutropenia. Store in tightly sealed containers at controlled room temperature to prevent hydrolysis. Handle with appropriate PPE due to potential toxicity.