Appearance:
white or off-white crystalline powder
Molecular Weight:
266.3
Density:
1.351 g/cm3
Boiling Point:
415.4 °C at 760 mmHg
Melting Point:
247℃
Flash Point:
205 °C
Refractive index:
1.671
Solubility:
In water, 100 mg/l @ neutral pH
Usage:
A potent (IC50=84nM) and selective non-nucleoside inhibitorf HIV-1 reverse transcriptase
Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in antiretroviral therapy. Its core synthesis involves condensation of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine derivatives. Molecular Formula: C15H14N4O; CAS No.: 129618-40-2.
Contraindicated in patients with severe hepatic impairment. Requires strict monitoring for hepatotoxicity and skin rashes. Store in cool, dry conditions below 25°C away from direct light.