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Overview
Pazopanib HCl is a multi-targeted tyrosine kinase inhibitor used in oncology. It functions by blocking VEGFR, PDGFR, and c-KIT. The compound features the molecular formula C21H26ClN5O with CAS No. 907845-57-8. Industrial synthesis involves precise condensation reactions under controlled pH.
Application
- Oncology Manufacturing: Active Pharmaceutical Ingredient (API) for renal cell carcinoma and soft tissue sarcoma therapies.
- Pharmaceutical Research: Used in preclinical studies for anti-angiogenesis mechanisms.
- Contract Manufacturing: Bulk supply for formulation of oral tablets.
Precautions
Store at 25°C in dry, dark conditions to maintain stability. Strictly avoid inhalation or skin contact during handling; use appropriate PPE. Clinical use requires monitoring of liver function and blood pressure due to potential toxicity profiles.