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Overview
Silodosin is a highly selective alpha-1A adrenergic receptor antagonist used in urology. Synthesized via chiral resolution and condensation, its molecular formula is C20H28N4O3S (CAS: 152719-26-1).
Application
- Treatment of Benign Prostatic Hyperplasia (BPH) symptoms.
- Management of urinary obstruction and retention in males.
- R&D for combination therapies with antihypertensives.
Precautions
Contraindicated in severe hepatic impairment. Store in cool, dry conditions below 25°C to maintain stability. Handle with PPE to avoid dermal absorption during manufacturing.