Appearance:
White Crystalline Solid
Molecular Weight:
390.83
Boiling Point:
629.1 °C at 760 mmHg
Flash Point:
334.3 °C
Usage:
L-Valine,2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester,hydrochloride (1:1) (CAS NO.175865-59-5) is used as a pro-drug of ganciclovir and used in treatment of retro-virus.
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Overview
Valganciclovir hydrochloride is a prodrug of ganciclovir used in antiviral therapy. Its molecular formula is C14H23ClN8O5P and CAS No. 176039-08-2. The core synthesis involves esterification followed by salt formation.
Application
- Treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients.
- Prevention of CMV disease in organ transplant recipients.
- Management of CMV infections in pediatric populations under specific protocols.
Precautions
Contraindicated in hypersensitivity cases; requires renal dose adjustment. Store below 25°C in dry conditions. Handle with PPE due to potential teratogenicity and carcinogenicity.