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Overview
Afatinib is a potent, irreversible ErbB family blocker used in oncology. Its core synthesis involves complex heterocyclic coupling reactions. The molecular formula is C22H25ClFN3O4 with CAS No. 850140-73-3.
Application
- Treatment of metastatic non-small cell lung cancer (NSCLC) with EGFR mutations.
- Targeted therapy for patients with specific sensitizing mutations.
- Research applications in kinase inhibitor pharmacology studies.
Precautions
Contraindicated in severe hepatic impairment. Requires strict moisture control during storage at 2-8°C. Personnel must use PPE to prevent dermal absorption due to cytotoxicity risks.