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Overview
Posaconazole is a broad-spectrum triazole antifungal agent. It inhibits fungal cytochrome P450-dependent 14α-demethylase, blocking ergosterol synthesis. Molecular formula: C37H42N8O4; CAS No.: 171228-49-2.
Application
- Invasive Aspergillosis prophylaxis in immunocompromised patients.
- Treatment of oropharyngeal candidiasis refractory to standard therapy.
- Management of invasive mucormycosis infections.
- Industrial synthesis of pharmaceutical intermediates.
Precautions
Contraindicated with drugs metabolized by CYP3A4 that prolong QT interval. Store below 25°C in dry conditions. Monitor liver enzymes and electrolytes during long-term therapy to prevent hepatotoxicity.