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Overview
Avatrombopag maleate is a second-generation thrombopoietin receptor agonist used to treat thrombocytopenia. It is synthesized via peptide coupling and salt formation processes. The compound features the molecular formula C28H34N6O6 and carries CAS number 1079524-79-8.
Application
- Hematology: Management of chronic ITP in adults.
- Oncology: Pre-procedural platelet count elevation for surgery.
- Clinical Trials: Investigating efficacy in liver disease-related thrombocytopenia.
Precautions
Strictly contraindicated in patients with severe hepatic impairment. Storage requires controlled room temperature (20-25°C) in moisture-proof containers. Clinical use mandates monitoring for thrombotic events and bone marrow fibrosis risks.