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Overview
Gefitinib is a small-molecule tyrosine kinase inhibitor primarily synthesized via condensation and cyclization reactions. It functions as an EGFR inhibitor for non-small cell lung cancer (NSCLC). The chemical formula is C22H24ClFN4O3 with CAS number 184475-35-6.
Application
- Oncology: First-line treatment for EGFR mutation-positive NSCLC.
- Pharmaceutical Manufacturing: API production for generic tablet formulations.
- Research & Development: Preclinical studies on tumor signaling pathways.
Precautions
Strictly contraindicated in patients with severe hepatic impairment. Store in a cool, dry place below 25°C away from direct sunlight. Personnel must utilize PPE to prevent inhalation or dermal exposure during handling.