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Overview
Nalfurafine is a selective kappa-opioid receptor agonist developed for treating intractable pruritus. The molecular formula is C28H39NO4 with CAS No. 100586-76-1, synthesized via complex chiral coupling processes.
Application
- Dermatology: Management of uremic and cholestatic pruritus.
- Pharmaceuticals: Formulation as oral tablets for chronic kidney disease patients.
- Research: Tool compound for opioid receptor pharmacology studies.
Precautions
Strictly contraindicated for acute pain management due to addiction risk. Store under controlled conditions at 2-8°C away from light. Handling requires PPE to prevent dermal absorption.