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Overview
Obeticholic Acid is a semi-synthetic derivative of chenodeoxycholic acid used primarily in hepatology. Its core synthesis involves the oxidation and functionalization of bile acid precursors. Molecular formula: C24H36O5; CAS No.: 128507-23-5.
Application
- Treatment of primary biliary cholangitis (PBC) as an adjunct to ursodeoxycholic acid.
- Management of non-alcoholic steatohepatitis (NASH) in clinical trials targeting fibrosis reduction.
- Bile acid sequestration studies for metabolic syndrome modulation.
Precautions
Contraindicated in patients with complete biliary obstruction. Strict storage required at controlled room temperature away from moisture. Clinical use mandates monitoring of liver enzymes and lipid profiles due to potential hepatotoxicity risks.